Material Safety Data Sheet
Neomycin Sulfate
Section 1 - Chemical Product and Company Identification
MSDS Name: Neomycin Sulfate
Catalog Numbers: 86-21790

Section 2 - Composition, Information on Ingredients 
CAS#1405-10-3
Chemical Name: Neomycin Sulfate
Percent  95%min
EINECS/ELINCS: 215-773-1
Hazard Codes:Xn
Risk Phrases: 42/43-22

Section 3 - Hazards Identification 
EMERGENCY OVERVIEW
Harmful if swallowed. Irritate to eyes, respiratory system and skin.

Potential Health Effects
Eye: Cause eye irritation.
Skin: Cause skin irritation. May be harmful if absorbed through the skin. May cause sensitization by skin contact.
Ingestion: Harmful if swallowed. May cause irritation of the digestive tract.
Inhalation: May cause respiratory tract irritation. May be harmful if inhaled.
Chronic: Limited evidence of a carcinogenic effect. 

Section 4 - First Aid Measures 
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin: Get medical aid. Flush skin with plenty of soap and water.
Ingestion: Get medical aid. Wash mouth out with water.
Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Notes to Physician: Treat symptomatically and supportively

Section 5 - Fire Fighting Measures 
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion. To extinguish fire use water spray, dry chemical, carbon dioxide, or appropriate foam.

Section 6 - Accidental Release Measures 
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks: Vacuum or sweep up material and place into a suitable disposal container. Do not let this chemical enter the environment.

Section 7 - Handling and Storage 
Handling: Wash thoroughly after handling. Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with eyes, skin, and clothing. Keep container tightly closed. Avoid ingestion and inhalation.
Storage:Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from light. Store with dessicant.

Section 8 - Exposure Controls, Personal Protection 
Engineering Controls: Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.

Personal Protective Equipment
Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin: Wear appropriate protective gloves to prevent skin exposure.
Clothing: Wear appropriate protective clothing to prevent skin exposure.
Respirators:Follow the OSHA respirator regulations found in 29CFR 1910.134 or European Standard EN 149. Always use a NIOSH or European Standard EN 149 approved respirator when necessary.

Section 9 - Physical and Chemical Properties 
Physical State: powder
Color: white
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available
Viscosity: Not available.
Boiling Point: 1046.1°C at 760 mmHg 
Freezing/Melting Point: >187°C (dec.)
Autoignition Temperature: Not available

Flash Point: 586.5°C 
Decomposition Temperature:Not available
Water Solubility: H2O: 50 mg/mL As a stock solution. Stock solutions should be filter sterilized and stored at 2-8°C. Stable at 37°C for 5 days.
Specific Gravity/Density:Not available
Molecular Formula: C23H48N6O17S
Molecular Weight: 712.72

Section 10 - Stability and Reactivity 
Chemical Stability: Stable under normal temperatures and pressures.
Conditions to Avoid: Incompatible materials.
Incompatibilities with Other Materials: Strong oxidizing agents.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported.

Section 11 - Toxicological Information 
RTECS#: QP4375000
CAS# 1405-10-3:
LD50/LC50: RTECS:QP4375000
CAS#1405-10-3:
Carcinogenicity:
Neomycin Sulfate,95%min - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Epidemiology: No information found
Other Studies: The toxicological properties have not been fully investigated. See actual entry in RTECS for complete information.

Section 12 - Ecological Information 
a health hazard

Section 13 - Disposal Considerations 
Dispose of in a manner consistent with federal, state, and local regulations.
WGK Germany : 3

Section 14 - Transport Information 
Shipping Name: not regular

Section 15 - Regulatory Information 
European Labeling in Accordance with EC Directives
      Hazard Class: Xn
        Risk Phrases:
            R42/43: May cause sensitization by inhalation and skin contact
            R22: Harmful if swallowed
       Safety Phrases:
            S23: Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)          
            S36/37: Wear suitable protective clothing and gloves
            S45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)  
            S22: Do not breathe dust
            S24/25: Avoid contact with skin and eyes 
       FLUKA BRAND F CODES:
            F8: Photosensitive.

Section 16 - Additional Information
While the information herein is believed to be reliable, it is furnished without warranty of any kind. It shall be used only as a guide. We assume no liabilities from the use of this product or information contained herein.